Page ContentMap and Directions Address: 2727 West Holcombe Blvd.Houston, Texas 77025From The North (From Downtown)Take 59 South to Kirby Drive. Exit Kirby and take a left under the freeway, going south on Kirby, (Past Bissonnett and Rice Village) until you get to Holcombe Boulevard.Make a right on Holcombe Boulevard.Go past Rice Epicurean Market.The Main Campus is on the left.Go to Brompton and make a U-turn or a left turn. Valet parking is available for patients near the St. Luke's ER entrance and general parking is located in the front and back of the campus.From The South, East or West (From the 610 Loop)Take 610 South and exit Kirby Drive.Go north on Kirby, passing Reliant Stadium, Main and Braeswood.Make a left on Holcombe Boulevard. Go past Rice Epicurean Market. The Main Campus is on the left.Go to the next light, which is Brompton and make a U-turn or a left turn.Valet parking is available for patients near the St. Luke's ER entrance and general parking is located in the front or back of the campus.