Alexander Ou, MD

Dr. Alexander Ou is a board-certified neurologist with fellowship training in Neuro-Oncology. He earned his Doctor of Medicine degree in 2015 at New York Medical College in Valhalla and completed his residency in 2019 at Stony Brook University Hospital in New York. Dr. Ou did his fellowship training in Neuro-Oncology in 2021 at The University of Texas MD Anderson Cancer Center in Houston.

He has conducted various neurology and neurology-oncology research projects in association with the National Heart Lung and Blood Institute, The University of Texas MD Anderson Cancer Center, and the Dana-Farber Cancer Institute. In addition, Dr. Ou is a published co-author of multiple scientific papers, abstracts, and book chapters.

Dr. Ou cared for patients at HCA Houston Healthcare prior to joining Kelsey Seybold in August 2022.

Dr. Ou enjoys cooking, traveling, exploring new restaurants, board sports, and spending time with family.

Fun Facts

As a child, Dr. Ou wanted to be a pyrotechnic chemist because he loved the idea of science and explosions. He was wisely steered toward a safer profession.

Awards

• William James Miller Endowed Fellowship Award, 2019 – 2020: Awarded for study of “Quality of End-of-Life Care in Patients with High-Grade Glioma,” under research mentor Dr. Rebecca Harrison. - Funded through the generous support of the Miller family, the Department of Neuro-Oncology, and Dr. Victor Levin
• Alpha Omega Alpha Honor Medical Society, Iota Chapter of New York Medical College, 2014: Elected to junior AOA for academic and clinical achievement
• Dana-Farber Cancer Institute Departmental Innovator Award, 2008: Awarded for intellectual and technical contributions to several ongoing projects in lab of Dr. Benz and Dr. Haung
• Dartmouth College Presidential Scholar Research Assistantship, 2006: Awarded to sophomore undergraduate students for demonstrated academic achievement

Publications and Presentations

• Ou, A., Ott, M., Fang, D., & Heimberger, A. B. (2021). The Role and Therapeutic Targeting of JAK/STAT Signaling in Glioblastoma. Cancers, 13(3), 437. https://doi.org/10.3390/cancers13030437
• Ou, A., Yung, W., & Majd, N. (2020). Molecular Mechanisms of Treatment Resistance in Glioblastoma. International journal of molecular sciences, 22(1), 351. https://doi.org/10.3390/ijms22010351
• Ou, A., Sumrall, A., Phuphanich, S., Spetzler, D., Gatalica, Z., Xiu, J., Michelhaugh, S., Brenner, A., Pandey, M., Kesari, S., Korn, W. M., Mittal, S., Westin, J., & Heimberger, A. B. (2020). Primary CNS lymphoma commonly expresses immune response biomarkers. Neuro-oncology advances, 2(1), vdaa018. https://doi.org/10.1093/noajnl/vdaa018
• Huang, S. C., Liang, J. Y., Vu, L. V., Yu, F. H., Ou, A.C., Ou, J. P., Zhang, H. S., Burnett, K. M., & Benz, E. J., Jr (2020). Epithelial-specific isoforms of protein 4.1R promote adherens junction assembly in maturing epithelia. The Journal of biological chemistry, 295(1), 191–211. https://doi.org/10.1074/jbc.RA119.009650
• Huang, S. C., Zhang, H. S., Yu, B., McMahon, E., Nguyen, D. T., Yu, F. H., Ou, A.C., Ou, J. P., & Benz, E. J., Jr (2017). Protein 4.1R Exon 16 3' Splice Site Activation Requires Coordination among TIA1, Pcbp1, and RBM39 during Terminal Erythropoiesis. Molecular and cellular biology, 37(9), e00446-16. https://doi.org/10.1128/MCB.00446-16
• Huang, S. C., Ou, A.C., Park, J., Yu, F., Yu, B., Lee, A., Yang, G., Zhou, A., & Benz, E. J., Jr (2012). RBFOX2 promotes protein 4.1R exon 16 selection via U1 snRNP recruitment. Molecular and cellular biology, 32(2), 513–526. https://doi.org/10.1128/MCB.06423-11
• Huang, S. C., Cho, A., Norton, S., Liu, E. S., Park, J., Zhou, A., Munagala, I. D., Ou, A.C., Yang, G., Wickrema, A., Tang, T. K., & Benz, E. J., Jr (2009). Coupled transcription-splicing regulation of mutually exclusive splicing events at the 5' exons of protein 4.1R gene. Blood, 114(19), 4233–4242. https://doi.org/10.1182/blood-2009-02-206219
• Zhou, A., Ou, A.C., Cho, A., Benz, E. J., Jr, & Huang, S. C. (2008). Novel splicing factor RBM25 modulates Bcl-x pre mRNA 5' splice site selection. Molecular and cellular biology, 28(19), 5924–5936. https://doi.org/10.1128/MCB.00560- 08

Abstracts

• Ou AC, Soomro Z, Bornstein C, Alfaro-Munoz K, de Groot J, Majd N. The Risk and Burden of Thromboembolic and Hemorrhagic Events in Patients with Malignant Glioma Receiving Bevacizumab. Accepted at Society for Neuro-Oncology (SNO) 2021 meeting.
• Ou AC, Kebriaei P, Tummala S. An Unusual Presentation of Radiation Necrosis in the Brainstem. Presented at American Academy of Neurology (AAN) 2021 Annual Meeting.
• Ou AC, Harrison RA, Liu D, Naqvi M, Naqvi SM, O’Brien BJ, Weathers SP, de Groot JF, Bruera E. Quality of End-of Life Care in Patients with High-Grade Glioma. Presented at Society for Neuro-Oncology (SNO) 2020 meeting
• Garrido-Sanabria E, Jones RA, Ou AC, Syritsyna O, Kowalska A, Coyle PK, Peyster R. A Case of Anti-Aquaporin-4 Antibody-Positive NMOSD Associated with Primary CNS Lymphoma. Presented at American Academy of Neurology (AAN) 2019 Annual Meeting.
• Ou AC, Heslin R, Kowalska A. Rare Malignant Transformation of an Epidermoid Cyst. Presented at American Academy of Neurology (AAN) 2018 Annual Meeting.
• Shehzad, U, Ou AC, Kowalska A. Rare Presentation of Malignant Myxomatous Aneurysms with PRKAR1A Gene Mutation. Presented at American Academy of Neurology (AAN) 2018 Annual Meeting.

Book Chapters

• Ou, AC, Weathers S. “Treatment and Prevention of Venous Thrombo-Embolism.” Brain Tumors: A Pocket Guide – Submitted
• Ou AC, O’Brien BJ. “Neurologic Complications of Breast Cancer.” Newton/Neurological Complications of Systemic Cancer and Antineoplastic Therapy, Second Edition. – Accepted
• 07/2019-06/2021 UCNS Review, M&M Conference, Neuro-Oncology Core Curriculum – prepared and gave lectures in fundamental topics in clinical neuro-oncology, as well as instructive clinical cases

Research

• 01/2020 – 06/2021 University of Texas MD Anderson, Dr. Nazanin Majd - Studying role of anticoagulation in high-risk glioma patients
• 08/2019 – 06/2021 University of Texas MD Anderson, Dr. Rebecca Harrison - Studying end-of-life quality of life measures in patients with high-grade gliomas
• 07/2017 – 06/2019 Stony Brook University Hospital, Dr. Samuel Ryu - Studied role of inflammation in gliomas
• 06/2012 – 09/2012 National Heart Lung and Blood Institute, Center for Molecular Medicine, Dr. Haiming Cao; - Investigated role of novel long non-coding RNAs in metabolic disease pathways
• 07/2007 – 07/2010 Dana-Farber Cancer Institute, Department of Medical Oncology, Dr. Edward Benz and Dr. Shu-Ching Huang - Studied changes in protein 4.1R isoform expression during erythrocyte differentiation and alternative splicing control of genes involved in apoptosis
• 06/2006 – 09/2006 Dartmouth College, Thayer School of Engineering, Dr. Brian Pogue - Studied near-infrared imaging and use of photosensitizers in cancer therapeutics - Designed and performed experiments and analyzed results
• 01/2005 – 06/2005 Dartmouth College, Dartmouth Medical School, Dr. William North – Studied NMDA receptor expression in small-cell lung cancer